HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 16221918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-(4-Aminobenzyl)thiomorpholine 1,1-dioxide | HCID 2779682 | — |
| Reactant | Dimethylaminopropyl carbodiimide hydrochloride | HCID 21899179 | — |
| Reactant | HCID 59822387 | HCID 59822387 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16221918 | HCID 16221918 | — |
Reaction Steps
A mixture of 5′-(cyclopropanecarbonyl-amino)-2′-methoxy-biphenyl-4-carboxylic acid (50 mg), 4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylamine (38 mg), N-methylmorpholine (0.03 ml), 1-hydroxybenzotriazole (21 mg) and 1-ethyl-3-(3-(dimethylaminopropyl)carbodiimide hydrochloride (30 mg) in dry DMF (1 ml) was stirred at 20 C for 18 h. The mixture was then added to water and the resulting colourless precipitate collected by filtration and dried (38 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cb8307d85b37464e9966becbdcb6ba7b |
| Source note | uspto-grants-2011_08 |