Methanol → HCID 59822356, compound

Participants

Reaction Steps

4′-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylcarbamoyl]-6-methyl-biphenyl-3-carboxylic acid methyl ester (565 mg) in dry THF (6 ml) was treated with a solution of lithium borohydride (2M in THF, 3.5 ml). The mixture was stirred at 20 C for 18 h. and was then treated with methanol (5 ml). The mixture was then evaporated and the residue partitioned between water and ethyl acetate. The dried extracts were evaporated giving the title compound as a colourless crystalline solid (505 mg).

Provenance & Evidence