HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → (R)-2-{6-Chloro-4'-[4-(4-methanesulfonyl-piperazin-1-ylmethyl)-phenylcarbamoyl]-biphenyl-3-ylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 4-(4-Methanesulfonyl-piperazin-1-ylmethyl)-phenylamine | HCID 11369231 | — |
| Reactant | (R)-2-(4'-Carboxy-6-chloro-biphenyl-3-ylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 67372818 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-2-{6-Chloro-4'-[4-(4-methanesulfonyl-piperazin-1-ylmethyl)-phenylcarbamoyl]-biphenyl-3-ylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 67370744 | — |
Reaction Steps
A mixture of (R)-2-(4′-Carboxy-6-chloro-biphenyl-3-ylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (100 mg), 4-(4-methanesulfonyl-piperazin-1-ylmethyl)-phenylamine (86 mg) and HBTU (121 mg) in dry DMF (4 ml) containing N-methylmorpholine (69 μl) was stirred at room temp for 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-1cc5ad6e155e4f11bc38ae533b2f275e |
| Source note | uspto-grants-2011_08 |