HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 3-Bromo-4-methoxy-N-(2-methyl-4-morpholin-4-yl-phenyl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 3-Bromo-4-methoxybenzoic acid | HCID 66836 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2-Methyl-4-(morpholin-4-yl)aniline | HCID 21955000 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Bromo-4-methoxy-N-(2-methyl-4-morpholin-4-yl-phenyl)-benzamide | HCID 67373984 | — |
Reaction Steps
A mixture of 3-bromo-4-methoxy-benzoic acid (247 mg), 2-methyl-4-morpholin-4-yl-phenylamine (205 mg), EDAC (410 mg), HOBT (289 mg) and N-methylmorpholine (353 μl) in DMF (5 ml) was stirred at room temperature for 18 h. The mixture was then diluted with water (30 ml) and the resulting solid collected by filtration and dried (464 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-21db227fd8794c53975053a0beeb9e4c |
| Source note | uspto-grants-2011_08 |