HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → 2'-Methoxy-5'-(2-methyl-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Ethoxycarbonylphenylboronic acid | HCID 2734350 | — |
| Reactant | 3-Bromo-4-methoxy-N-(2-methyl-4-morpholin-4-yl-phenyl)-benzamide | HCID 67373984 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2'-Methoxy-5'-(2-methyl-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid | HCID 67374349 | — |
Reaction Steps
A mixture of 3-Bromo-4-methoxy-N-(2-methyl-4-morpholin-4-yl-phenyl)-benzamide (432 mg) and 4-(ethoxycarbonyl)-phenyl boronic acid (311 mg) in 2:1 DME:water (15 ml) containing cesium carbonate (697 mg) and tetrakis(triphenylphosphine)palladium0 (127 mg) was heated to reflux for 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-96690057a1ce48d18410318896f3af9d |
| Source note | uspto-grants-2011_08 |