HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2'-Chloro-5'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Benzenamine, 4-(4-morpholinyl)- | HCID 75655 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-Chloro-3-(4-ethoxycarbonylphenyl)benzoic acid | HCID 53227884 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2'-Chloro-5'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester | HCID 59822360 | 35.8% |
Reaction Steps
A mixture of 6-chloro-biphenyl-3,4′-dicarboxylic acid 4′-ethyl ester (800 mg), N-(4-aminophenyl)morpholine (469 mg), EDAC (504 mg), HOBT (355 mg) and N-methylmorpholine (578 μl) in DMF (10 ml) was stirred at room temperature. After 1 h, water (80 ml) was added and the resulting suspension filtered. The residue was then purified by chromatography. Elution with 1:1 ethyl acetate:petrol gave a yellow crystalline solid (437 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-9bcd9d97c1074522826b802369c66e15 |
| Source note | uspto-grants-2011_08 |