HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2'-Chloro-5'-(2-fluoro-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 3-Fluoro-4-morpholinoaniline | HCID 1485330 | — |
| Reactant | 4-Chloro-3-(4-ethoxycarbonylphenyl)benzoic acid | HCID 53227884 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2'-Chloro-5'-(2-fluoro-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester | HCID 67371223 | — |
Reaction Steps
A mixture of 6-chloro-biphenyl-3,4′-dicarboxylic acid 4′-ethyl ester (213 mg), 3-fluoro-4-morpholin-4-yl-phenylamine (179 mg), EDAC (174 mg), HOBT (123 mg) and N-methylmorpholine (200 μl) in DMF (3 ml) was stirred at room temperature. After 11 h, water (30 ml) was added and the resulting suspension filtered. The residue was then purified by chromatography. Elution with 1:1 ethyl acetate:petrol gave a brown oil (235 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-2a74595c25314e6dad8db0b72a887e34 |
| Source note | uspto-grants-2011_08 |