Hydrochloric Acid → HCID 23136406, compound

Participants

Reaction Steps

To a mixture of methyl (E)-3-[4-[(2,3-dihydro-1H-inden-1-yl)oxy]-3,5-difluorophenyl]-2-propenoate (0.52 g, 1.6 mmol), samarium (1.2 g, 7.9 mmol), tetrahydrofuran (3 mL) and methanol (7 mL) was added iodine (0.80 g, 3.2 mmol), and the reaction mixture was stirred at room temperature overnight. 1 N Hydrochloric acid (20 mL) was added thereto, and the mixture was stirred for 20 minutes, then diluted with water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated. The residue was purified with silica gel column chromatography (hexane/ethyl acetate=10:1) to give the title compound. Yield 60%.

Provenance & Evidence