Methanol → Methyl Ferulate

Participants

Reaction Steps

To a solution of (E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid (3.0 g, 15 mmol) in methanol (30 mL) was added sulfuric acid (0.5 mL), and the mixture was heated under reflux for 12 hours. After the reaction solution was returned to room temperature, water was added thereto, and the reaction mixture was extracted with ethyl acetate. The extract was washed with water, and then concentrated under reduced pressure to give the title compound (3.1 g, yield 97%) as an oily matter. The obtained compound was used in the next reaction without purification.

Provenance & Evidence