Hydrochloric Acid → HCID 23136426, compound

Participants

Reaction Steps

A mixture of ethyl 3-{3-fluoro-4-[(3-phenoxybenzyl)oxy]phenyl}-2-methylpropanoate (127 mg, 0.31 mmol), a 2 N aqueous sodium hydroxide solution (1 mL) and ethanol (2 mL) was stirred at 60° C. for 1.5 hours. The reaction solution was ice-cooled and acidified with 1 N hydrochloric acid, and then the solvent was distilled off under reduced pressure. The residue was dissolved in methylene chloride (5 mL), and the mixture was washed with water and saturated brine and dried over magnesium sulfate. The solvent was then distilled off under reduced pressure to give the title compound (93 mg, 78%) as an oily matter.

Provenance & Evidence