Trifluoroacetic acid → HCID 23136295, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(4-{[3-(2-tert-butoxy-2-oxoethoxy)benzyl]oxy}-3-fluorophenyl)propanoate (0.43 g, 0.98 mmoL) in dichloromethane (15 mL) was added trifluoroacetic acid (1.1 g, 9.80 mmoL), and the mixture was stirred at 50° C. for, 1 hour. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate=9:1) to give the title compound (0.26 g, yield 72%) as white powders.

Provenance & Evidence