Triethylamine → HCID 23136340, compound

Participants

Reaction Steps

A solution of (3-{[4-(3-ethoxy-3-oxopropyl)-2-fluorophenoxy]methyl}phenoxy)acetic acid (0.34 g, 0.90 mmol), methylamine hydrochloride (0.073 g, 1.08 mmol), triethylamine (0.22 g, 2.16 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.21 g, 1.08 mmol) and 1-hydroxybenzotriazole (0.15 g, 1.08 mmol) in DMF (7 mL) was stirred at room temperature for 18 hours. Then, water was added to the reaction mixture and extracted with ethyl acetate. The organic layer was washed successively with saturated brine and water, and concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate=2:8) to give the title compound (0.34 g, yield 97%) as an oily matter.

Provenance & Evidence