Methyl iodide → HCID 23136312, compound

Participants

Reaction Steps

To a solution of ethyl 3-{3-fluoro-4-[(3-hydroxy-5-phenoxybenzyl)oxy]phenyl}propanoate (0.30 g, 0.73 mmol) and methyl iodide (2.2 mL, 14.6 mmol) in acetone (10 mL) was added potassium carbonate (0.52 g, 3.76 mmol), and the mixture was heated under reflux and stirred for 4 hours. The reaction solution was diluted with ethyl acetate, filtered, washed with water, and then concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate=7:3) to give the title compound (0.31 g, yield 99%) as an oily matter.

Provenance & Evidence