HCID 67131071, compound → HCID 67131189, compound

Participants

Reaction Steps

Zinc powder (14.7 g, 225 mmol) was added to a suspension of 3-chloro-2-(4-chloro-phenyl)-5,6-difluoro-2H-indazole (16.8 g, 56 mmol) in acetic acid (118 ml). The suspension was heated under reflux conditions for 2 h. The hot solution was filtered, the filtrate was poured onto ice water/brine 1/1 and extracted two times with TBME. The combined extracts were washed with ice water/brine 1/1 and dried over Na2SO4. The solvent was removed under reduced pressure to give a brown solid which was crystallized from dichloromethane/n-heptane to give the title compound (12.1 g, 46 mmol; 81%) as brown crystals. MS: m/e=265.1 [M+H+].

Provenance & Evidence