HuagongsheHuagongshe Chemistry Print Report · For research reference only
[rac]-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-acetic acid → [rac]-2-[2-(4-Chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-2-cyclohexyl-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [rac]-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-acetic acid | HCID 67131115 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [rac]-2-[2-(4-Chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-2-cyclohexyl-ethanol | HCID 67131080 | — |
Reaction Steps
In analogy to the procedure described in example 29.1, [rac]-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-acetic acid (example 24.7) was reduced using borane-tetrahydrofuran complex in THF to give the title compound as off-white foam. MS: m/e=391.1 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008505B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cfdd5403833341208c2f1a0722ec09af |
| Source note | uspto-grants-2011_08 |