Sodium Hydroxide → HCID 178515666, compound

Participants

Reaction Conditions

Reaction Steps

Hydrobromic acid (100 mL; manufactured by Wako Pure Chemical Industries, Ltd.) was added to 1-(6-methoxy-3-trifluoromethylindazol-1-yl)ethanone (2.5826 g) that can be produced by the method described in Reference Example 34 or the like, and the mixture was stirred overnight at 110° C. The reaction solution was cooled to 0° C., and then was neutralized with a 5 mol/L aqueous solution of sodium hydroxide to adjust the pH to about 7. The reaction solution was extracted once with ethyl acetate. The organic layer was washed with brine, and was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and thus the title compound (1.8583 g) was obtained.

Provenance & Evidence