Methanol → HCID 59370742, compound

Participants

Reaction Conditions

Reaction Steps

(R)-N-benzyl-N-(3-(2-(benzyl-(2-hydroxyethyl)amino)-1-(triethylsilyloxy)ethyl)phenyl)methanesulfonamide (500 mg; an intermediate described in Reference Example 1 of WO 03/035620) was dissolved in THF (1.76 mL; manufactured by Wako Pure Chemical Industries, Ltd.) and methanol (1.76 mL; manufactured by Wako Pure Chemical Industries, Ltd.) under a nitrogen atmosphere, and 20% palladium hydroxide on carbon-49.94% wet with water (102.7 mg; manufactured by N.E. Chemcat Corp.) was added thereto. Subsequently, the reaction system was purged with hydrogen, and under a hydrogen atmosphere, the reaction solution was stirred for 15 hours at 50° C. The reaction solution was cooled to room temperature, purged with nitrogen, and then filtered. The filtrate was concentrated under reduced pressure, and thus the title compound (364 mg) was obtained.

Provenance & Evidence