Triphenylphosphine → HCID 59373762, compound

Participants

Reaction Steps

Tert-butyl 3-ethyl-6-hydroxyindazole-1-carboxylate (27.9 mg) that can be produced by the method described in Reference Example 14 or the like, and a (R)-tert-butyl 5-(2-(benzyl(2-hydroxyethyl)amino)-1-(triethylsilyloxy)ethyl)-2-chlorophenyl(methylsulfonyl)carbamate-toluene solution [0.5 mL; solution prepared by dissolving (R)-tert-butyl 5-(2-(benzyl(2-hydroxyethyl)amino)-1-(triethylsilyloxy)ethyl)-2-chlorophenyl(methylsulfonyl)carbamate (1.5265 g) that can be produced by the method described in Reference Example 75 or the like in dehydrated toluene (10 mL)] were dissolved in dehydrated toluene (0.5 mL), and triphenylphosphine (54.9 mg; manufactured by Wako Pure Chemical Industries, Ltd.) and TMAD (41.4 mg; manufactured by Masuda Chemical Industries, Co., Ltd.) were added to the solution. The mixture was stirred for 3 days at room temperature. The reaction solution was purified by column chromatography (“COLUMN-B”; n-hexane:ethyl acetate=85:15→64:36), and thus the title compound (85.6 mg) was obtained.

Provenance & Evidence