Hydrazine → 2-[4-(1,3-dioxolan-2-yl)phenyl]-5-hydrazinyl-3-phenyl-1,6-Naphthyridine

HRID 1678735노트

반응식

HRID 1678735 반응식
Cl[C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:6]([C:12]1[CH:17]=[CH:16][C:15]([CH:18]3[O:22][CH2:21][CH2:20][O:19]3)=[CH:14][CH:13]=1)=[N:7]2.[NH2:29][NH2:30]>O1CCOCC1>[O:22]1[CH2:21][CH2:20][O:19][CH:18]1[C:15]1[CH:16]=[CH:17][C:12]([C:6]2[C:5]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[N:11][C:2]=3[NH:29][NH2:30])[N:7]=2)=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 575007255-Chloro-2-[4-(1,3-dioxolan-2-yl)phenyl]-3-phenyl-1,6-naphthyridine

생성물 1

HCID 594729242-[4-(1,3-dioxolan-2-yl)phenyl]-5-hydrazinyl-3-phenyl-1,6-Naphthyridine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
100 °C

실험 절차

A suspension of 5-chloro-2-(4-[1,3]dioxolan-2-yl-phenyl)-3-phenyl-[1,6]naphthyridine (3-3, 5.2 g, 13.4 mmol) and anhydrous hydrazine (5 mL) in anhydrous 1,4-dioxane (15 mL) was heated at 100° C. in a microwave reactor for 5 min. The reaction mixture was cooled, concentrated and dried with toluene azotropically to give the title compound as a solid. LRMS m/z (M+1) Calcd: 385.2. Found 385.3.

후처리

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. dry with materialdried with toluene azotropically

출처 및 근거

ORD 기록
ord-c16402f9c56c4e1bbe2f107903e6b8b0
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008317B2

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