Hydrazine → HCID 178514340, compound

HRID 1678759Notes

Reaction equation

HRID 1678759 reaction equation
Cl[C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:6]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]4[NH:29][C:28]([C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=5)=[N:27][N:26]=4)[CH2:21][CH2:20]3)=[CH:14][CH:13]=1)=[N:7]2.[NH2:42][NH2:43]>O1CCOCC1>[C:36]1([C:5]2[C:6]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][N:19]4[CH2:24][CH2:23][CH:22]([C:25]5[NH:29][C:28]([C:30]6[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=6)=[N:27][N:26]=5)[CH2:21][CH2:20]4)=[CH:16][CH:17]=3)=[N:7][C:8]3[C:3]([CH:4]=2)=[C:2]([NH:42][NH2:43])[N:11]=[CH:10][CH:9]=3)[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 178478337HCID 178478337, compound

Product 1

HCID 178514340HCID 178514340, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 8-8 (4.3 g, 7.7 mmol) in 30 mL 1,4-dioxane and hydrazine (7.4 g, 231.1 mmol) was heated in a microwave reactor at 100° C. for 5 mins. The mixture was cooled and concentrated to remove solvents. Toluene 40 mL (×3) was added and removed under vacuum to remove the residual hydrazine. The desired product 8-9 was obtained as a solid.

Workup

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated
  3. customto remove solvents
  4. additionToluene 40 mL (×3) was added
  5. customremoved under vacuum
  6. customto remove the residual hydrazine

Sources & evidence

ORD record
ord-d60f3367eaee4e31880b73154d018bc8
Source dataset
uspto-grants-2011_08
Patent number
US08008317B2

Reaction notes

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