反应详情

To a stirred solution of 3-3 (16 g, 41.1 mMol) in anhydrous 1,4-dioxane (75 mL) at 0° C. was added 3N HCl (27 mL). The reaction was then allowed to reach room temperature and was stirred for around 3 hours. Upon completion, the reaction was quenched with saturated NaHCO3 solution to reach a pH of >7. The product was extracted into ethyl acetate (3×150 mL). The combined organic layers were washed with brine, dried with Na2SO4 and MgSO4, filtered and concentrated in vacuo to yield 4-(5-chloro-3-phenyl-1,6-naphthyridin-2-yl)benzaldehyde 9-1 as a tan solid. LC/MS (M+1) calculated: 345.8; observed: 345.0

1. customto reach room temperature
2. customUpon completion, the reaction was quenched with saturated NaHCO3 solution
3. extractionThe product was extracted into ethyl acetate (3×150 mL)
4. washThe combined organic layers were washed with brine
5. dry with materialdried with Na2SO4 and MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo