Hydrazine → HCID 178514342, compound

HRID 1678771Notes

Reaction equation

HRID 1678771 reaction equation
Cl[C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:6]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]4[NH:29][C:28]([C:30]5[N:35]=[CH:34][CH:33]=[CH:32][N:31]=5)=[N:27][N:26]=4)[CH2:21][CH2:20]3)=[CH:14][CH:13]=1)=[N:7]2.[NH2:42][NH2:43]>O1CCOCC1>[NH:42]([C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:6]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]4[NH:29][C:28]([C:30]5[N:35]=[CH:34][CH:33]=[CH:32][N:31]=5)=[N:27][N:26]=4)[CH2:21][CH2:20]3)=[CH:14][CH:13]=1)=[N:7]2)[NH2:43]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 178478339HCID 178478339, compound

Product 1

HCID 178514342HCID 178514342, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a stirred solution of 11-2 (0.4 g, 0.7 mMol) in anhydrous 1,4-dioxane (3 mL) was added hydrazine (0.45 mL, 14.5 mMol). The solution was heated to 100° C. in a microwave reactor for 5 minutes. The solvent was removed in vacuo and was dried azeotropically with toluene three times to yield 11-3.

Workup

  1. customThe solvent was removed in vacuo
  2. dry with materialwas dried azeotropically with toluene three times
  3. customto yield 11-3

Sources & evidence

ORD record
ord-a4966dc8573640099adb229dde78ce5d
Source dataset
uspto-grants-2011_08
Patent number
US08008317B2

Reaction notes

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