HCID 178525123, compound → HCID 178420874, compound

HRID 1678788Notes

Reaction equation

HRID 1678788 reaction equation
[NH:1]1[CH:5]=[N:4][C:3]([CH:6]2[CH2:11][CH2:10][N:9](C(OCC3C=CC=CC=3)=O)[CH2:8][CH2:7]2)=[N:2]1>C(O)C.[Pd]>[NH:1]1[CH:5]=[N:4][C:3]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)=[N:2]1

Participants

4

Reactant 1

HCID 178525123HCID 178525123, compound

Product 1

HCID 178420874HCID 178420874, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl 4-(1H-1,2,4-triazol-3-yl)piperidine-1-carboxylate (7.3 g, 25 mmol) in ethanol (100 mL) was added 10% palladium on carbon (500 mg) and the reaction vessel was purged with hydrogen and stirred over an atmosphere of hydrogen for 3 hours. The reaction was filtered and concentrated to give 21-1 as a solid. MS (M+Hf): 153.2; 1H-NMR (400 MHz, DMSO-d6): δ 7.99 (s, 1H), 2.98-2.94 (m, 2H), 2.82-2.74 (m, 1H), 2.57-2.50 (m, 2H), 1.82-1.78 (m, 2H), 1.60-1.50 (m, 2H).

Workup

  1. customthe reaction vessel was purged with hydrogen
  2. filtrationThe reaction was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-79ba918cf822491bb714fa288cc29590
Source dataset
uspto-grants-2011_08
Patent number
US08008317B2

Reaction notes

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