Hydrazine → HCID 178514343, compound

HRID 1678790Notes

Reaction equation

HRID 1678790 reaction equation
Cl[C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:6]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]4[NH:29][CH:28]=[N:27][N:26]=4)[CH2:21][CH2:20]3)=[CH:14][CH:13]=1)=[N:7]2.[NH2:36][NH2:37]>O1CCOCC1>[NH:36]([C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:6]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]4[NH:29][CH:28]=[N:27][N:26]=4)[CH2:21][CH2:20]3)=[CH:14][CH:13]=1)=[N:7]2)[NH2:37]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 178478340HCID 178478340, compound

Product 1

HCID 178514343HCID 178514343, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a stirred solution of 21-2 (0.4 g, 0.8 mMol) in anhydrous 1,4-dioxane (3 mL) was added hydrazine (0.45 mL, 14.5 mMol). The solution was heated to 100° C. in a microwave reactor for 5 minutes. The solvent was removed in vacuo and was dried azeotropically with toluene three times to yield 21-3.

Workup

  1. customThe solvent was removed in vacuo
  2. dry with materialwas dried azeotropically with toluene three times
  3. customto yield 21-3

Sources & evidence

ORD record
ord-752c322e99bb49a5be09e5372ebb28ff
Source dataset
uspto-grants-2011_08
Patent number
US08008317B2

Reaction notes

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