HCID 57500733, compound → HCID 58524640, compound

Participants

Reaction Steps

To a solution of N-{(1E)-[4-(5-chloro-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methylene}-2-methylpropane-2-sulfinamide (34-1, 4.53 g, 10.1 mmol) in methylene chloride (100 mL) was added methyl magnesium bromide (30 mL, 42.0 mmol, 1.4M in 75:25 toluene:THF) at −10° C. After 30 minutes, the reaction was quenched by addition of saturated ammonium chloride solution (while maintaining the temperature below 0° C.) and extracted with methylene chloride. The combined organics were washed with water, brine, dried over magnesium sulfate, filtered and concentrated to give the title compound as a pale yellow solid. MS (M+H+): calculated=464.03, observed=464.2

Provenance & Evidence