HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperonal → 2-Benzo[1,3]dioxol-5-yl-2-[6-chloro-2-(cyclohexyl-methoxy-methyl)-5-fluoro-benzoimidazol-1-yl]-N-cyclohexyl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperonal | HCID 8438 | — |
| Reactant | 3-Chlorophenylacetic acid | HCID 15879 | — |
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Reactant | 2-Cyclohexyl-2-methoxyacetic acid | HCID 21505102 | — |
| Reactant | 2-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide | HCID 67373623 | — |
| Product | 2-Benzo[1,3]dioxol-5-yl-2-[6-chloro-2-(cyclohexyl-methoxy-methyl)-5-fluoro-benzoimidazol-1-yl]-N-cyclohexyl-acetamide | HCID 67374265 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with piperonal ([CAS RN 120-57-0]) and (3-chloro-phenyl)-acetic acid with DL-cyclohexyl-methoxy-acetic acid ([CAS RN 15540-18-8]). MS (ISP): 556.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008503B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-b024fae26f844879bf4598a66a6a4b56 |
| Source note | uspto-grants-2011_08 |