HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenylacetic acid → 2-[6-Chloro-5-fluoro-2-(methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-cyclopentyl-2-(4-methoxy-phenyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenylacetic acid | HCID 15879 | — |
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Reactant | 4-Methoxybenzaldehyde | HCID 31244 | — |
| Reactant | Cyclohexyl isocyanide | HCID 79129 | — |
| Reactant | Methoxyphenylacetic acid | HCID 107202 | — |
| Reactant | Cyclopentyl Isocyanide | HCID 2734784 | — |
| Reactant | 2-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide | HCID 67373623 | — |
| Product | 2-[6-Chloro-5-fluoro-2-(methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-cyclopentyl-2-(4-methoxy-phenyl)-acetamide | HCID 67371640 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with anisaldehyde ([CAS RN 123-11-5]), (3-chloro-phenyl)-acetic acid with DL- -methoxyphenylacetic acid ([CAS RN 7021-09-2]) and cyclohexyl isocyanide with cyclopentyl isocyanide ([CAS RN 68498-54-4]). MS (ISP): 522.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008503B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-6f3a437fa5b04918a82265a2209038da |
| Source note | uspto-grants-2011_08 |