Piperonal → 2-(6-Chloro-benzo[1,3]dioxol-5-yl)-2-[6-chloro-5-fluoro-2-(methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-cyclopentyl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Piperonal	HCID 8438	—
Reactant	3-Chlorophenylacetic acid	HCID 15879	—
Reactant	Cyclohexanecarboxaldehyde	HCID 16275	—
Reactant	Cyclohexyl isocyanide	HCID 79129	—
Reactant	Methoxyphenylacetic acid	HCID 107202	—
Reactant	Cyclopentyl Isocyanide	HCID 2734784	—
Reactant	2-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide	HCID 67373623	—
Product	2-(6-Chloro-benzo[1,3]dioxol-5-yl)-2-[6-chloro-5-fluoro-2-(methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-cyclopentyl-acetamide	HCID 67372690	—

Reaction Steps

The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with piperonal ([CAS RN 120-57-0]), (3-chloro-phenyl)-acetic acid with DL- -methoxyphenylacetic acid ([CAS RN 7021-09-2]) and cyclohexyl isocyanide with cyclopentyl isocyanide ([CAS RN 68498-54-4]). MS (ISP): 570.2 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08008503B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-078b7b4ac0974954b61d1cef9d0259ec
Source note	uspto-grants-2011_08