HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1678873Generated: October 26, 2026
Thiophenol → Ethyl 2-phenylthio-4-methyl-5-thiazolecarboxylate
https://huagongshe.com/reaction/1678873
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate | HCID 2824057 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-phenylthio-4-methyl-5-thiazolecarboxylate | HCID 20364661 | 98.5% |
Reaction Steps
A suspension of ethyl 2-bromo-4-methyl-5-thiazolecarboxylate (22 g), thiophenol (10.75 g) and potassium carbonate powder (24.3 g) in dimethylformamide (100 ml) is stirred for 4 hours at 80° C. The reaction mixture is treated in the same manner as in Example 1 to give ethyl 2-phenylthio-4-methyl-5-thiazolecarboxylate (24.2 g) boiling at 160°-161° C at 1 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04077968 |
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| Source dataset | uspto-grants-1978_03 |
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| ORD ID | ord-9e5e8529e0a04289a38b9b4ade8e8c60 |
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| Source note | uspto-grants-1978_03 |
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