1,2,3,6-Tetrahydro-4-phenylpyridine → HCID 20364539, compound

HRID 1678885Notes

Reaction equation

HRID 1678885 reaction equation
[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:14]1(C2CCNCC=2)[CH:19]=[CH:18]C=[CH:16][CH:15]=1.OC1(C2C=CC=CC=2)CCN(CCCC[N:37]2[CH:46]([OH:47])[C:45]3[CH:48]=[CH:49][CH:50]=[C:43]4[C:44]=3[C:39](=[CH:40][CH:41]=[CH:42]4)[C:38]2=[O:51])CC1>>[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][N:5]([CH2:16][CH2:15][CH2:14][CH2:19][CH2:18][N:37]2[CH:46]([OH:47])[C:45]3[CH:48]=[CH:49][CH:50]=[C:43]4[C:44]=3[C:39](=[CH:40][CH:41]=[CH:42]4)[C:38]2=[O:51])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 825531,2,3,6-Tetrahydro-4-phenylpyridineHCID 963874-Phenylpiperidin-4-olHCID 20364510HCID 20364510, compound

Product 1

HCID 20364539HCID 20364539, compound

Procedure

Following the procedure of example 5 but substituting 4-hydroxy-4-phenylpiperidine for the 4-phenyl-1,2,3,6-tetrahydropyridine in part (b), one obtains the titled compound.

Sources & evidence

ORD record
ord-adede4a7817e431ba5c2d32ec2535c81
Source dataset
uspto-grants-1978_03
Patent number
US04077958

Reaction notes

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