Potassium 3-(N-acetylglycyl)dithiocarbazate → HCID 178474654, compound

HRID 1678905Notes

Reaction equation

HRID 1678905 reaction equation
[C:1]([NH:4][CH2:5][C:6]([NH:8][NH:9][C:10]([S-:12])=[S:11])=O)(=[O:3])[CH3:2].[K+]>S(=O)(=O)(O)O>[C:1]([NH:4][CH2:5][C:6]1[S:11][C:10]([SH:12])=[N:9][N:8]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 23686815Potassium 3-(N-acetylglycyl)dithiocarbazate

Product 1

HCID 178474654HCID 178474654, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Potassium 3-(N-acetylglycyl)dithiocarbazate (102.3 g) was added bit by bit to concd. sulfuric acid (1 liter) at 0° to 5° C and the mixture was stirred for an hour at the same temperature. The reaction mixture was added dropwise on crushed ice (c.a. 10 kg) under stirring. Precipitating crystals were collected by filtration to give 5-acetamidomethyl-1,3,4-thiadiazole-2-thiol (54.5 g). m.p. 200° to 203° C.

Workup

  1. additionThe reaction mixture was added dropwise
  2. customPrecipitating crystals
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-62e95a5dc5ef4b44888b136dbb7dcb36
Source dataset
uspto-grants-1978_03
Patent number
US04077965

Reaction notes

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