2-Chloro-N,N-dimethylethylamine → HCID 86735519, compound

Participants

Reaction Steps

A solution of N-benzyloxycarbonyl-6-aminocaproic acid, (2.65 g, 0.010 mole) in ethyl acetate (60 ml) was treated with triethylamine (2.8 ml, 0.020 mole) and 1.48M β-dimethylaminoethyl chloride (17 ml, 0.025 mole) and refluxed for 16 hrs. The reaction mixture was filtered and the filtrate extracted with saturated NaCl (3 × 50 ml), 5% NaHCO3 (3 × 50 ml), saturated NaCl (3 × 50 ml), dried over MgSO4, filtered and evaporated to dryness. The product was obtained as a viscous oil, 1.55 g (46.1%).

Provenance & Evidence