2-[3-(2-Hydroxyphenyl)acryloyl]benzoic acid → HCID 12260520, compound

Participants

Reaction Steps

12.7 g of o-(o-hydroxycinnamoyl)benzoic acid was heated in 100 ml of N-dimethylformamide under agitation for 6 hours. Then, the liquid reaction mixture was poured into 400 ml of water to form a white crystal. The crystal was recovered by filtration and recrystallized from ethyl alcohol to obtain 10.7 g of 2H-chromene-2-spiro-3'-phthalide (compound (1)) as a colorless needle. (yield = 90%). Physical properties of the product are as follows:

Provenance & Evidence