反应详情

7.6 g of ethyl 2-[p-(4-tetrahydropyranyl)-phenoxy]-propanoate were added to a solution of 17 ml of 2N sodium hydroxide and 100 ml of ethanol and the mixture was stirred for 2 hours at room temperature and then was refluxed for 30 minutes. The mixture was evaporated to dryness and the residue was dissolved in 20 ml of N sodium hydroxide. The solution was washed with ether and acidified with 4N hydrochloric acid. The mixture was filtered and the recovered crystals were washed with water and dried. The product was crystallized from a 50-50 cyclohexane-ethyl acetate mixture to obtain 6.1 g of 2-[p-(4-tetrahydropyranyl)-phenoxy]-propanoic acid melting at 156° C.

1. temperaturewas refluxed for 30 minutes
2. customThe mixture was evaporated to dryness
3. dissolutionthe residue was dissolved in 20 ml of N sodium hydroxide
4. washThe solution was washed with ether
5. filtrationThe mixture was filtered
6. washthe recovered crystals were washed with water
7. customdried
8. customThe product was crystallized from a 50-50 cyclohexane-ethyl acetate mixture