Sodium Hydroxide → HCID 20365473, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 14.6 g of ethyl 2-[p-(4-tetrahydropyranyl)-phenoxy]-butanoate, 100 ml of ethanol and 40 ml of 2N sodium hydroxide was stirred at 20° C for 24 hours and then refluxed for an hour. The ethanol was evaporated and the residue was taken up in 100 ml of 0.5N sodium hydroxide. The solution was washed with ether and acidified with concentrated hydrochloric acid and was extracted with methylene chloride. The extracts were dried and evaporated to dryness to obtain 13.2 g of raw product which was crystallized from cyclohexane to obtain 12.2 g of 2-[p-(4-tetrahydropyranyl)-phenoxy]-butanoic acid melting at 127° C.

Provenance & Evidence