HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(2-Chloro-4-phenylbutyl)imidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(2-Hydroxy-4-phenylbutyl)imidazole | HCID 13457355 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Chloro-4-phenylbutyl)imidazole hydrochloride | HCID 20365268 | — |
Reaction Steps
A solution of 1.00 g. of 1-(2-hydroxy-4-phenylbutyl) imidazole in 40 ml. of dichloromethane was treated with 1 ml. of thionyl chloride with stirring and the solution heated to gentle reflux for one hour. Evaporation to dryness afforded 1-(2-chloro-4-phenylbutyl) imidazole hydrochloride as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04078071 |
| Source dataset | uspto-grants-1978_03 |
| ORD ID | ord-34751d25808c422b92aac66fa3792dfd |
| Source note | uspto-grants-1978_03 |