Nitric Acid → HCID 70624302, compound

HRID 1678988Notes

Reaction equation

HRID 1678988 reaction equation
[N+:1]([O-:4])([OH:3])=[O:2].[Cl:5][C:6]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:7]=1[CH2:8][O:9][CH:10]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>>[N+:1]([O-:4])([OH:3])=[O:2].[Cl:5][C:6]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:7]=1[CH2:8][O:9][CH:10]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 203651751-[2-(2,4-Dichlorobenzyloxy)-4-phenylbutyl]imidazole

Product 1

HCID 70624302HCID 70624302, compound

Procedure

Nitric acid (70%; d = 1.42) was added dropwise to a stirred solution of 2.0 g. of 1-[2-(2,4-dichlorobenzyloxy)-4-phenylbutyl]imidazole in 30 ml. of anhydrous ether until precipitation was complete. The product was filtered off, washed with ether, air dried, and recrystallized from ethyl acetate to yield 1-[2-(2,4-dichlorobenzyloxy)-4-phenylbutyl]imidazole nitrate, m.p. 121°--124° C.

Workup

  1. customof anhydrous ether until precipitation
  2. filtrationThe product was filtered off
  3. washwashed with ether, air
  4. customdried
  5. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-b934f313c148494da12ea218a0de0eb9
Source dataset
uspto-grants-1978_03
Patent number
US04078071

Reaction notes

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