Glycerol → HCID 20364901, compound

HRID 1678994Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[OH:10][CH2:11][CH:12]([CH2:14]O)[OH:13]>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]1[O:10][CH2:11][CH:12]([OH:13])[CH2:14][O:5]1

Participants

Reactant 2

HCID 753Glycerol

HCID 67970o-Fluorobenzaldehyde

Product 1

HCID 20364901HCID 20364901, compound

Procedure

Using the method of Example 5g, except no solvent was necessary, 24.8 g 2-fluorobenzaldehyde and 18.4 g glycerol were reacted to form 2-(2-fluorophenyl)-5-hydroxy-1,3-dioxane. The product was cooled and dissolved in 100 ml ether. The ether solution was washed with an aqueous potassium carbonate solution, dried with magnesium sulfate, filtered and evaporated under reduced pressure. The resultant oil was distilled, and that fraction distilling at 140°-145° C/10-5 mm contained 2-(2-fluorophenyl)-5-hydroxy-1,3-dioxane.

Sources & evidence

ORD record: ord-72d288c6f3374de880bde66d39fa96b6
Source dataset: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04077982

Reaction notes

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