Benzene, 1-(chloromethyl)-2-fluoro- → HCID 178505635, compound

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Reaction Steps

Using the method of Example 8, cis-5-hydroxy-2-phenyl-1,3-dioxane (8.4 g, 0.047 mole) was reacted with sodium hydride (2.0 g of 61%, 0.047 mole). The reactant sodium salt was reacted with 2-fluorobenzyl chloride (7.2 g, 0.05 mole) to give, after recrystallization from benzene-ligroin, 2.8 g of white solid, m.p. 65°-67° C, and on further recrystallization, a solid, m.p. 70°-71° C. Analysis by VPC indicated the product to be 90% cis-5-(2-fluorobenzyloxy)-2-phenyl-1,3-dioxane.

Provenance & Evidence