Glycerol → HCID 20364901, compound

Participants

Reaction Steps

A mixture of 2-fluorobenzaldehyde (24.8 g, 0.2, mole), glycerol (18.4 g, 0.2 mole) and 40% sulfuric acid (2 ml) was heated at 80°-100° C for 12 hours. The mixture cooled to room temperature and 100 ml of ether was added. The solution was washed with 2% potassium carbonate solution, dried over magnesium sulfate and concentrated under reduced pressure. The oil which remained (28.7 g) was distilled under 1 × 10-5 mm to give a product (18 g) which distilled at a pot temperature of 140°-145° C. This product was identified by infrared and elemental analysis as 5-hydroxy-2-(2-fluorophenyl)-1,3-dioxane.

Provenance & Evidence