Benzyl Chloride → HCID 20364895, compound

Participants

Reaction Steps

5-Hydroxy-2-(2-fluorophenyl)-1,3-dioxane (18.0 g, 0.09 mole) was reacted with sodium hydride and benzyl chloride (13.0 g, 0.09 mole) as described in Example 2, except that the slurry was heated at 80°-100° C for 12 hours. The product was isolated in the manner described in Example 2 to give 12.1 g of oil which was distilled under 1 × 10-5 mm to give a product (6.2 g) which distilled at a pot temperature of 165°-170° C. VPC analysis of this product indicated it to contain 32% cis-5-benzyloxy-2-(2-fluorophenyl)-1,3-dioxane.

Provenance & Evidence