2-(Chloromethyl)thiophene → HCID 20364967, compound

HRID 1679024Notes

Reaction equation

HRID 1679024 reaction equation
[OH:1][C@H:2]1[CH2:7][O:6][C@@H:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4][CH2:3]1.Cl[CH2:15][C:16]1[S:17][CH:18]=[CH:19][CH:20]=1>>[C:8]1([CH:5]2[O:4][CH2:3][CH:2]([O:1][CH2:15][C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)[CH2:7][O:6]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 698302-(Chloromethyl)thiopheneHCID 178521647HCID 178521647, compound

Product 1

HCID 20364967HCID 20364967, compound

Procedure

Using the procedure of Example 56, cis-5-hydroxy-2-phenyl-1,3-dioxane was reacted with 2-chloromethylthiophene to give, after repeated recrystallization from petroleum ether, cis-2-phenyl-5-(2-thienyl)methoxy-1,3-dioxane m.p. 68.5°-69°. The ir and nmr spectra were consistent with the assigned structure.

Workup

  1. customto give
  2. customrecrystallization from petroleum ether, cis-2-phenyl-5-(2-thienyl)methoxy-1,3-dioxane m.p. 68.5°-69°

Sources & evidence

ORD record
ord-5aa32d65aa4942168f60fd183402e44d
Source dataset
uspto-grants-1978_03
Patent number
US04077982

Reaction notes

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