Pivalaldehyde → HCID 20364892, compound

HRID 1679027Notes

Reaction equation

HRID 1679027 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][O:5][C:6]([CH3:11])([CH2:9][OH:10])[CH2:7][OH:8].[CH3:16][C:17]([CH3:21])([CH3:20])[CH:18]=O>C1C=CC=CC=1>[C:17]([CH:21]1[O:10][CH2:9][C:6]([O:5][CH2:4][C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=2[F:1])([CH3:11])[CH2:7][O:8]1)([CH3:20])([CH3:18])[CH3:16]

Participants

4

Reactant 2

HCID 12417PivalaldehydeHCID 20364943HCID 20364943, compound

Product 1

HCID 20364892HCID 20364892, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Using the procedure of Example 51, 2-(2-fluorobenzyloxy)-2-methyl-1,3-propanediol and 2,2-dimethylpropanal were reacted, using benzene as solvent, to give, after separation by column chromatography, r-2-(tert-butyl)-t-5-(2-fluorobenzyloxy)-5-methyl-1,3-dioxane, m.p. 50°-52°; and r-2-(tert-butyl)-C-5-(2-fluorobenzyloxy)-5-methyl-1,3-dioxane, m.p. 85°-87°. The ir and nmr spectra were consistent with the assigned structures.

Workup

  1. customwere reacted
  2. customto give
  3. customafter separation by column chromatography, r-2-(tert-butyl)-t-5-(2-fluorobenzyloxy)-5-methyl-1,3-dioxane, m.p. 50°-52°

Sources & evidence

ORD record
ord-dcfceea31e7b43aca230a151db87e95b
Source dataset
uspto-grants-1978_03
Patent number
US04077982

Reaction notes

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