Propanal → HCID 20364948, compound

HRID 1679029Notes

Reaction equation

HRID 1679029 reaction equation
[CH:1](=[O:4])[CH2:2][CH3:3].[CH2:5]([C:7]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])([CH2:10]O)[CH2:8][OH:9])[CH3:6]>CCCCCC>[CH2:2]([CH:1]1[O:9][CH2:8][C:7]([CH2:5][CH3:6])([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[CH2:10][O:4]1)[CH3:3]

Participants

4

Reactant 2

HCID 527PropanalHCID 20364888HCID 20364888, compound

Product 1

HCID 20364948HCID 20364948, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Using the procedure of Example 51, propionaldehyde and 2-ethyl-2-(2-fluorobenzyloxy)-1,3-propanediol were reacted, using hexane as solvent, to give, after separation by column chromatography, r-2-ethyl-5-ethyl-t-5-(2-fluorobenzyloxy)-1,3-dioxane, b.p. 89°-90°/0.01 mm, nD26 1.4895; and r-2-ethyl-5-ethyl-c-51 -(2-fluorobenzyloxy)-1,3-dioxane, b.p. 93°-95°/0.01 mm, nD26 1.4902. The ir and nmr spectra were consistent with the assigned structures.

Workup

  1. customwere reacted
  2. customto give
  3. customafter separation by column chromatography, r-2-ethyl-5-ethyl-t-5-(2-fluorobenzyloxy)-1,3-dioxane, b.p. 89°-90°/0.01 mm

Sources & evidence

ORD record
ord-68bbb6700a3143a38ff02cdfbf9fffbe
Source dataset
uspto-grants-1978_03
Patent number
US04077982

Reaction notes

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