HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cholesterol → Dihydroergotamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cholesterol | HCID 5997 | — |
| Reactant | Ethylene Oxide | HCID 6354 | — |
| Reactant | Dihydroergotamine mesylate | HCID 71171 | — |
| Reactant | Sodium Diacetate | HCID 23662384 | — |
| Solvent | Water | HCID 962 | — |
| Product | Dihydroergotamine | HCID 10531 | — |
Reaction Steps
60 mg of dihydroergotamine mesylate are added together with 1.5 g of cholesterin ethoxylated with approx. 24 mols of ethylene oxide a) to 60 cc of water adjusted to pH 4.1 with a buffer mixture of sodium acetate/acetic acid, and homogenized with a polytron homogenizer. The clear liquid is filled into bottles fitted with droppers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04078065 |
| Source dataset | uspto-grants-1978_03 |
| ORD ID | ord-130b022a09fb456faddbc73aef3aa100 |
| Source note | uspto-grants-1978_03 |