Diethyl Carbonate → Ethyl 3-[3-(trifluoromethyl)phenyl]-2H-isoindole-1-carboxylate

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Reaction Steps

According to the procedure described in Example 1, 1,3-dihydro-1-methyl-5-(α,α,α-trifluoro-m-tolyl)-2H-1,4-benzodiazepin-2-one is reacted with diethylcarbonate in the presence of sodium hydride, and there is obtained 3-(α,α,α-trifluoro-m-tolyl)-isoindole-1-carboxylic acid ethyl ester, having a melting point of 155°-157° C. Recrystallization from ethanol does not increase the melting point.

Provenance & Evidence