反应详情

In order to obtain the free base, the hydrobromide obtained according to the previous paragraph is treated with 2-N sodium carbonate in the presence of ether. The ethereal extract, shielded from light, is washed with water, dried over sodium sulfate and evaporated. The residue crystallizes on trituration with ether. Recrystallization from ether/hexane yields almost colorless crystals of 2-(2-aminoethyl)-5-chloro-3-phenylisoindole-1-carboxylic acid ethyl ester; melting point 84°-86° C.

1. customIn order to obtain the free base
2. extractionThe ethereal extract
3. washis washed with water
4. dry with materialdried over sodium sulfate
5. customevaporated
6. customThe residue crystallizes on trituration with ether
7. customRecrystallization from ether/hexane