Chloroacetonitrile → HCID 20364091, compound

Temperature

25 °C

1,2,4-Triazole (3.45 g) was added to a sodium methoxide in methanol [prepared from sodium (1.15 g) and methanol (40 ml)], and the mixture was refluxed for 1 hour, and cooled to 25° C; chloroacetonitrile (3.78 g) was then added and the mixture was refluxed for a further 6 hours. The solution was filtered and the solvent removed in vacuo. The resultant mixture was dissolved in petroleum ether (50 ml; b.p. 40°-60° C) and the solution filtered to remove unreacted 1,2,4-triazole. Removal of the solvent in vacuo gave a residue which on distillation gave the title compound.

1. temperaturethe mixture was refluxed for 1 hour
2. temperaturethe mixture was refluxed for a further 6 hours
3. filtrationThe solution was filtered
4. customthe solvent removed in vacuo
5. dissolutionThe resultant mixture was dissolved in petroleum ether (50 ml; b.p. 40°-60° C)
6. filtrationthe solution filtered
7. customto remove unreacted 1,2,4-triazole
8. customRemoval of the solvent in vacuo
9. customgave a residue which
10. distillationon distillation

ORD record

ord-cc05a6a5247d4c12bd604b28eaed1263

Source dataset

uspto-grants-1978_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04079143