反应详情

By following the manipulative procedure outlined above in Example 12, a solution of 5.43 g of 1-(2-dimethylaminoethyl)-1-(4-methoxyphenyl)cyclopentane (the free base of Example 46) in chloroform is added to a stirred solution of 2.57 g of cyanogen bromide in chloroform to give an oil. The oil is dissolved in chlorofrom, subjected to column chromatography with a silica gel column and eluted with ether to produce an orange oil of 1-(N-cyano-N-methylaminoethyl)-1-(4-methoxyphenyl)cyclopentane.

1. customto give an oil
2. dissolutionThe oil is dissolved in chlorofrom
3. washeluted with ether