HCID 86735542, compound → HCID 131711053, compound

Participants

Reaction Steps

A mixture of p-nitrobenzyl 7-azido-6-methylthio-3-acetoxymethyl-3-methylsulfonyloxy-cepham-4-carboxylate (20 mg.) and EM silica gel 60 (500 mg.) in 3:1 φH-EtOAc (1 ml.) is stirred at room temperature for 4 hours. The mixture is diluted with EtOAc (3 ml.) and filtered through a small sintered glass funnel containing a pad of MgSO4. The silica gel is washed with more EtOAc (2 × 2 ml.). Evaporation of the filtrate in vacuo provides a 3:7 mixture (19 mg.) of starting material and p-nitrobenzyl 7-azido-6-methylthio-3-acetoxymethyl-ceph-3-em-4-carboxylate.

Provenance & Evidence